Fluorescent water soluble polymers for isozyme-selective interactions with matrix metalloproteinase-9

用于与基质金属蛋白酶-9进行同工酶选择性相互作用的荧光水溶性聚合物

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Abstract

Matrix metalloproteinases (MMPs) are overexpressed in various pathological conditions, including cancers. Although these isozymes have similar active sites, the patterns of exposed amino acids on their surfaces are different. Herein, we report the synthesis and molecular interactions of two water soluble, fluorescent polymers which demonstrate selective interactions with MMP-9 compared to MMP-7 and -10.

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