Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials

利用流式细胞术发现新型抗疟药物,以应对疟疾耐药性挑战

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Abstract

A new flow cytometry method that uses an optimized DNA and RNA staining strategy to monitor the growth and development of the Plasmodium falciparum strain W2mef has been used in a pilot study and has identified Bay 43-9006 1, SU 11274 2, and TMC 125 5 as compounds that exhibit potent (<1 microM) overall and ring stage in vitro antimalarial activity.

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