Abstract
OBJECTIVE: To test the hypothesis that the predictive value for risk of fatal ischaemic heart disease associated with Lewis phenotypes depends on the level of leisure time physical activity. DESIGN: Prospective study controlling for alcohol, tobacco, serum cotinine, blood pressure, body mass index, serum lipids, work related physical activity, and social class. SETTING: The Copenhagen male study, Denmark. SUBJECTS: 2826 white men aged 53-75 years without overt cardiovascular disease; 266 (9.4%) had the Le(a-b-) phenotype. MAIN OUTCOME MEASURE: Incidence of death from ischaemic heart disease during 11 years. RESULTS: 107 men died of ischaemic heart disease. Among men with a low level of leisure time physical activity (