Abstract
AIM: This register-based study aimed to investigate differences in adverse neonatal outcomes between neonates born to mothers with and without type 1 diabetes in Sweden. METHODS: A nationwide cohort study was conducted using the Swedish Medical Birth Register, including all singleton births from 22 gestational weeks between 2010 and 2022. The neonatal outcomes among neonates of women with and without type 1 diabetes were studied with descriptive statistics and logistic regressions. Adjusted odds ratios (aORs) with 95% confidence intervals are presented. RESULTS: The study consisted of 1 402 394 neonates, and 0.5% had a mother with type 1 diabetes. Neonates of mothers with type 1 diabetes had increased odds of stillbirth (aOR 2.54; 95% CI 1.98-3.28), congenital malformations (aOR 1.66; 95% CI 1.50-1.84), preterm birth (aOR 3.80; 95% CI 3.41-4.23), large for gestational age (aOR 22.0; 95% CI 20.9-23.1), hypoglycaemia (aOR 45.85; 95% CI 43.60-48.22), and neonatal death (aOR 4.1; 95% CI 3.00-5.83). CONCLUSION: Neonates of mothers with type 1 diabetes continue to experience poorer neonatal outcomes, highlighting the need for more research on the causes and how care can be improved for their mothers during pregnancy.