Abstract
AIM: To prospectively evaluate the use of bubble continuous positive airway pressure (CPAP) in children with very severe pneumonia and other acute lower respiratory infections, during its trial introduction in a low resource hospital in Papua New Guinea. METHODS: Prospective observational study of children treated with CPAP who had severe pneumonia and severe respiratory distress with hypoxaemia (SpO(2) <90%). CPAP was driven by oxygen concentrators in which the fraction of inspired oxygen could be adjusted, and using low-resistance tubing and nasal oxygen prongs. RESULTS: A total of 64 children were commenced on CPAP: 29 (45.3%) survived and were discharged well, 35 (54.7%) died. Prior to commencing CPAP, the median SpO2 was 78% (IQR 53.3-86.8%), at one hour SpO(2) was 92% (IQR 80-97.75%, n = 64), and at 84 hours (3½ days) 98% (IQR 93-98%, n = 29), in survivors at each of these time points. A higher SpO(2) at one hour after commencement of CPAP predicted survival (p = 0.013), and human immunodeficiency virus infection was an independent predictors of death (p = 0.017). Technical and clinical problems encountered are described. CONCLUSION: Bubble CPAP improved oxygenation and reduced the severity of respiratory distress in some children with severe pneumonia; however, mortality was high reflecting high severity of illness and comorbidities. CPAP requires a quality system to be safe and effective.