A Nef Precursor or Benign Counterpart: High Prevalence of Healthy Subjects with Antibody Reactivity to the C3-Convertase

There are two anticonvertase antibody populations—Nephritic Factors which cause complement dysregulation and C3CAbs which do not. C3CAbs are highly prevalent in the healthy adult population (>95% prevalence). C3CAbs suggest a direction of study to determine the origin of Nephritic Factors.