Abstract
Activating dioxygen for the selective oxidation of alkanes remains a significant challenge in chemical synthesis. A key limitation lies in identifying efficient electron donors that can partially reduce and thus activate dioxygen while remaining stable in the presence of the resulting reactive oxygen species. Additionally, uncontrolled radical pathways often compromise chemoselectivity in reactions where O(2) is used as oxidant. In this study, we report a pyrrole-proline diketopiperazine (DKP) catalyst that synergizes with manganese complexes to activate dioxygen for selective C-H oxidation of alkanes. This strategy achieves high chemoselectivity across diverse substrates under aerobic conditions and delivers moderate to good yields, particularly for benzylic and strained cyclic alkanes.