Abstract
Aqueous proton transfer reactions are fundamental in biology and chemistry, yet kinetics and mechanisms of strong base-weak acid reactions are not well understood. In this work, we present a temperature-dependent reaction kinetic study of the water-soluble photobase actinoquinol, in the presence and absence of succinimide, a weak acid reaction partner. We study the temperature dependence of the reaction and connect the observed dynamics to the reaction's thermodynamics. We find that actinoquinol reacts in associated complexes with water/succinimide, creating an intermediate complex that can undergo either dissociation to create products, or reverse proton transfer within the complex to recreate the initial reactants. We find that the intermediates' formation is energetically unfavorable with both reaction partners, which impacts the net reaction rates. We also find that the net reaction rate is additionally strongly influenced by the competition between the dissociation of the intermediates and their reverse reaction.