Silver-Catalyzed Decarboxylative Coupling of Oxamic Acids with Styrenes to Synthesize E-Cinnamamides: A Distinguish Reaction Pathway

银催化草酰胺酸与苯乙烯脱羧偶联合成E-肉桂酰胺:一种独特的反应路径

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Abstract

A silver-catalyzed decarboxylative coupling of oxamic acids with styrenes has been developed to produce E-cinnamamides. Oxamic acids act as efficient precursors for carbamoy radicals. Based on the mechanistic experiments and intermediate analysis, the proposed mechanism involves radical addition to styrenes, followed by oxidation and solvent participation, ultimately leading to the formation of cinnamamides which is different from the reported cases.

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