Ru(phen)(3) Cl(2) -Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes

Ru(phen)3Cl2催化未活化烯烃的氯三氟甲基化反应

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Abstract

A novel Ru(phen)(3) Cl(2) -catalyzed free-radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8-aminoquinoline-derived inert enamides were reacted with the Togni regent to afford a broad range of Cl-containing trifluoromethyl derivatives in good yields. The reaction proceeded at 90 °C and experimental result shows that the chlorine source of the products originated from LiCl.

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