The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9
ncBAF 复合物通过 BRD9 的 H3K27ac 感应来调节 AML 中的转录
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作者：David C Klein, Santana M Lardo, Sarah J Hainer
Significance
The bromodomain-containing protein BRD9 is essential for AML cell viability, but it is unclear whether this requirement is due to the protein's role as an epigenetic reader. We inhibited this activity and identified altered gene-distal chromatin regulation and transcription consistent with a more mature myeloid cell state.
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