Abstract
Exercise and rehabilitation interventions are essential for health restoration, yet reviews on related clinical trials remain limited despite increasing research interest. This study analyzed the characteristics, designs, sample sizes, and outcome variables of clinical trials registered with the Clinical Research Information Service in South Korea, focusing on exercise and rehabilitation interventions. A systematic search using "exercise" and "rehabilitation" identified 1,089 trials registered up to June 9, 2024, with 470 meeting the inclusion criteria. Most studies (79.79%) were retrospectively registered, and 45.11% were open-label trials. Behavioral interventions (26.60%) and medical devices (22.34%) were most common, targeting circulatory (27.45%) and musculoskeletal (19.79%) conditions. Frequently assessed outcomes included 'balance,' 'pain,' and 'walking.' A notable increase in trials was observed since 2017. However, the high proportion of retrospective registrations and open-label designs highlights the need for more prospective and blinded trials to enhance research quality.