Abstract
BACKGROUND: Celiac disease (CD) is an autoimmune disorder related to the gluten and can be also associated with some other endocrine disorders such as type 1 diabetes and thyroid disease. Gluten exposure in CD may have especial role in developing other auto immune disorder. CASE PRESENTATION: We reported two familial cases with celiac disease who were on a gluten free diet (GFD) and hyperthyroidism and type 1 diabetes were appeared following a regular diet. Their autoimmune disorders were ameliorated after avoidance of dietary gluten. CONCLUSIONS: These cases highlighted the role of gluten exposure in developing other autoimmune disorders associated with CD, especially in young patients whom they are not cooperative to keep GFD. We recommended to evaluate the organ specific antibodies for risk assessment in these patients.