Abstract
BACKGROUND: Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder. Growing evidence suggests a significant association between IBS and psychological problems, such as anxiety and depression. This study was conducted to assess the prevalence of anxiety and depression in Vietnamese patients diagnosed with IBS according to Rome IV criteria. METHODS: This cross-sectional study recruited 186 consecutive patients who underwent outpatient clinic visits and colonoscopy for gastrointestinal symptoms. IBS diagnosis was established using the validated Rome IV criteria. Anxiety and depression were assessed using a validated Vietnamese version of the Hospital Anxiety and Depression Scale (HADS). RESULTS: The mean age of IBS patients was 49.5 ± 12.0 years, with females comprising 53.8%. IBS-M was the most prevalent subtype (39.8%), followed by IBS-C (39.2%) and IBS-D (21.0%). Using the HADS cut-off of ≥ 11 points for probable anxiety and depression, the prevalence was 21.0% and 11.8%, respectively. Expanding the criterion to a HADS of ≥ 8, indicating significant symptoms, increased the prevalence to 55.9% for anxiety and 40.8% for depression disorders. Patients with IBS-C, IBS-D, or IBS-M exhibited a significantly higher risk of depressive disorders compared to those without IBS, with odds ratios of 4.261, 7.013, and 6.585, respectively (p < 0.001). Additionally, men were less likely than women to experience depressive disorders. CONCLUSION: The findings revealed a high prevalence of depression and anxiety disorders among Vietnamese patients with IBS. Those with the IBS-M or IBS-D subtypes and a greater number of gastrointestinal symptoms were more likely to experience higher levels of depression and anxiety, particularly women.