Abstract
Dubin-Johnson syndrome is a rare, autosomal recessive hereditary disease, commonly known as "black liver disease." It is of great interest for surgeons to accidentally find the "black liver" during laparoscopic cholecystectomy (LC). We performed an emergency LC for cholecystolithiasis with Dubin-Johnson syndrome in 2013. We only performed cholecystectomy and liver tissue biopsy. Following a 5-year follow-up period, the patient does not appear to have abdominal pain and any other discomfort. Dubin-Johnson syndrome has no significant relationship with the occurrence of cholecystolithiasis and generally requires no special treatment. It is necessary to avoid misdiagnosis and overtreatment in the clinic.