Abstract
PURPOSE: To study the impact of smell loss on quality of life in patients with Coronavirus Disease 2019 (COVID-19), and assess the importance of olfaction before and after the loss of smell. In addition, to assess the impact of smell loss on psychological well-being and distress, and to assess coping strategies used by COVID-19 patients with smell loss. METHODS: This study was a cross-sectional study. A total of 487 COVID-19 positive patients with anosmia were recruited. All participants filled in the validated Multi-Clinic Smell and Taste Questionnaire, and the validated General Well-being Schedule. RESULTS: Negative impacts of smell loss, associated risks, interference with daily activities, and deterioration in well-being were common. The importance of the sense of smell was evaluated (In relation to other senses) as higher in the period after the loss than before the loss (p < 0.001). All aspects of health-related QOL are statistically significant (p < 0.001), with the exception of financial security and friendship, which are not statistically significant (p = 0.129, p = 0.334), respectively. Psychological well-being was negatively affected, and the use of both problem- and emotion-focused strategies was common. CONCLUSION: COVID-19 Patients with loss of smell have significant reductions in health-related QOL. Their loss of smell directly affects daily activities related to the olfactory function. Therefore, priority should be given to diagnose and treat the loss of smell. Patients who have recently developed smell loss may be offered a combination of the problem- and emotion-focused strategies to cope with their condition.