Abstract
OBJECTIVE: This study aimed to assess the health-related quality of life (HRQoL) in patients with Meige syndrome and to explore the associations among socio-demographic factors, depression, sleep quality, and HRQoL. METHODS: A cross-sectional study was conducted using a convenience sampling method. Data were collected between March and June 2025 from six tertiary hospitals located in Henan Province and Guangdong Province. A total of 376 valid questionnaires were collected. Four instruments were used, including the socio-demographic characteristics questionnaire, the Self-Rating Depression Scale, the Pittsburgh sleep quality index, and the Short-From 36 Health Survey. RESULTS: The current study reported a mean SF-36 score of 49.6 ± 13.2 among patients with Meige syndrome, indicating moderate HRQoL impairment. The present study identified a negative correlation between HRQoL score with depression score and sleep quality score. Multiple linear regression showed that disease duration (β = 0.17, P < 0.001), self-care ability (β = -0.13, P = 0.013), depression (β = -0.14, P = 0.006) and sleep quality (β = -0.12, P = 0.021) were significant factors associated with HRQoL in Meige syndrome patients. CONCLUSION: Patients with Meige syndrome exhibited moderate impairment in HRQoL. Depression and poor sleep quality were significantly associated with lower HRQoL.