Abstract
Objective: This systematic review evaluates the current applications, advantages, and challenges of large language models (LLMs) in melanoma care. Methods: A systematic search was conducted in PubMed and Scopus databases for studies published up to 23 July 2024, focusing on the application of LLMs in melanoma. The review adhered to PRISMA guidelines, and the risk of bias was assessed using the modified QUADAS-2 tool. Results: Nine studies were included, categorized into subgroups: patient education, diagnosis, and clinical management. In patient education, LLMs demonstrated high accuracy, though readability often exceeded recommended levels. For diagnosis, multimodal LLMs like GPT-4V showed capabilities in distinguishing melanoma from benign lesions, but accuracy varied, influenced by factors such as image quality and integration of clinical context. Regarding management advice, ChatGPT provided more reliable recommendations compared to other LLMs, but all models lacked depth for individualized decision-making. Conclusions: LLMs, particularly multimodal models, show potential in improving melanoma care. However, current applications require further refinement and validation. Future studies should explore fine-tuning these models on large, diverse dermatological databases and incorporate expert knowledge to address limitations such as generalizability across different populations and skin types.