Abstract
Following the global increase in atherosclerotic cardiovascular diseases, the demand for the effective identification of high-risk factors that lead to atherosclerotic plaque rupture and the search for new therapeutic targets has also increased. Neovascularization within plaques is widely recognized as an important indicator of plaque vulnerability. Thus, the timely detection of neovascularization within plaques and early intervention treatment can help reduce the potential adverse cardiovascular events caused by plaque rupture. This article introduces the formation mechanism, clinical significance, detection techniques, and prevention strategies for neovascularizing atherosclerotic plaques.