Abstract
BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) commonly exhibit overlooked left ventricular and atrial hypertrophy. This research identifies potential risk factors and intervention targets. METHODS: T2DM patients with normal ejection fraction values were enrolled, while we eliminated influences on heart size, such as hypertension and coronary heart disease. Variables for each participant, including height, weight, age, body mass index (BMI), and blood biochemistry, were recorded before patients were categorized into four groups based on heart size. Multiple linear regression and Pearson's correlation analyses were applied to investigate the possible correlations. RESULTS: Three years of clinical data were collected for each T2DM patient, while patients with incomplete data or interference factors affecting heart size were excluded. BMI, adjusted fasting blood glucose (FBG), glomerular filtration rate (eGFR), and age all showed a significant positive correlation with the inner diameter of the left ventricle and atrium in groups exhibiting hypertrophy. CONCLUSIONS: In T2DM patients, BMI correlated positively with left ventricular enlargement, suggesting its potential role as a risk factor. Weight control may be an effective intervention for left ventricular enlargement, to reduce the likelihood of heart failure.