Vulnerability to diet-induced obesity is associated with greater food priming-induced reinstatement of palatable food seeking

易患饮食诱导性肥胖与食物刺激后对美味食物的渴求恢复程度较高有关

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Abstract

We examined whether individual differences in weight gain during exposure to a "junk-food" diet were related to differences in later relapse-like behavior in a rat model. Following free access to a junk-food diet for 7 weeks, rats were trained to press a lever for palatable food pellets. Following extinction training, rats were tested for cue- and pellet priming-induced reinstatement. Results showed that rats prone to obesity while on the junk-food diet displayed greater pellet priming-, but not cue-, induced reinstatement relative to obesity-resistant rats, suggesting that obesity vulnerability is a factor determining one's chances for some types of relapse.

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