Abstract
BACKGROUND: Malnutrition, post-stroke depression (PSD), post-stroke anxiety (PSA), and post-stroke fatigue (PSF) in stroke survivors have complex relationships and are associated with adverse stroke outcomes. AIMS: This research aims to explore the temporal and directional relationships between malnutrition, PSD, PSA, and PSF after stroke in older adults. METHODS: Patients aged 65 years and older with their first ischemic stroke from two centers were selected and assessed at baseline, 3 months and 12 months. Malnutrition was evaluated using the Controlling Nutritional Status (CONUT) score, the Geriatric Nutritional Risk Index (GNRI), and the Prognostic Nutritional Index (PNI). PSD, PSA and PSF were measured with 24-item Hamilton Depression Scale (HAMD-24), 14-item Hamilton Anxiety Scale (HAMA-14) and Fatigue Severity Scale (FSS), respectively. The cross-lagged panel model (CLPM) was employed to investigate the temporal and directional relationships among these variables. RESULTS: Among the 381 older patients included, 54.33%, 43.57%, and 7.87% were found to have malnutrition according to the CONUT, GNRI, and PNI scores, respectively. Significant bidirectional relationships were found between malnutrition and PSD, as well as between PSD, PSA, and PSF, but no significant bidirectional relationships between malnutrition, PSA and PSF were observed, irrespective of the malnutrition index used (CONUT, GNRI, or PNI). CONCLUSIONS: Nutritional status and post-stroke neuropsychiatric disorders in older stroke survivors are worthy of attention. Specifically, early malnutrition after stroke can predict later PSD and vice versa. PSD, PSA, and PSF are mutually predictable. Further studies are required to investigate the mechanisms of these findings.