Abstract
OBJECTIVE: In this report, the effects of cynomorium flavonoids on mouse model of perimenopausal depression were investigated. METHOD: 60 ovariectomized female mice were randomly divided into 6 groups evenly: high, medium and low doses of cynomorium flavonoids groups (400 mg kg(-1), 200 mg kg(-1), 100 mg kg(-1)), Gengnian'an capsule group (675 mg kg(-1)), soy isoflavones soft capsule group (250 mg kg(-1)), and model group. Give the corresponding drug five days after surgery once a day, consecutive thirty days. The model group and control group were given the water of same volume. The model related groups were applied with different stress for consecutive eighteen days. Kill the mice and remove the thymus, spleen, uterus and one hand of brain when it is 2 h after the last administration in mice of each group. Observe the histological changes of each group under light microscope. RESULTS: By observing the pathological section, compared with model group, the pathological changes of the uterus and hypothalamus of mice were significantly improved. The thymic cortex markedly thickened, volume of splenic nodule also significantly increased, and the number of lymphocytes significantly increased (p < 0.01). Simulation results show that the high dose of cynomorium flavonoids group has the best effective. CONCLUSION: Cynomorium flavonoids on mouse uterus, hypothalamus, thymus and spleen lesions have a significant role in the improvement. Cynomorium flavonoids have a good therapeutic effect on mice with perimenopausal depression.