Abstract
The platelet factor 4 (PF(4)) and β-thromboglobulin (β-TG) were measured to evaluate the platelet activation in vivo in patients with ischemic heart disease. The results are summarized as follows: 1. In patients with acute myocardial infarction, the PF(4) and the β-TG levels were significantly higher compared to those of normal controls (P<0.005). 2. In patients with angina pectoris, the PF(4) and the β-TG levels were not signivicantly different from those of normal controls. 3. A pattern of decline in the PF(4) and the β-TG level was shown in patients with acute myocardial infarction by day 10. In conclusion, the measurement of PF(4) and β-TG is a useful method to detect the platect activation in vivo in the patients with ischemic heart disease.