Abstract
INTRODUCTION: Renal biopsy remains an essential tool for the diagnosis and treatment of patients with medical kidney disease. Recently, there has been a perceived change in the number of inadequate samples. The aim of this study was to determine the native renal biopsy miss rate from 2005 to 2020 at Arkana Laboratories, a nationwide kidney biopsy service. METHODS: From 2005 to 2020, a total of 123,372 native kidney biopsies were received from >2500 nephrologists practicing across 44 US states. The miss rate was determined by age and year. In a subset of biopsies received in 2005 and 2018, the biopsy operator was determined, nephrologist or radiologist. Furthermore, the miss rate, needle gauge, biopsy depth by operator, and biopsy core width by gauge were measured. RESULTS: The miss rate increased markedly from 2% in 2005 to 14% in 2020. Radiologists performed 5% of biopsies in 2005 and 95% in 2018 using smaller diameter (18g/20g) needles 92% of the time. Glomeruli per centimeter of core biopsy and mean core width were significantly lower with smaller needles. The miss rate deep was significantly lower for nephrologists and remained consistent within operator between the 2 time points. The miss rate did not correlate with the increasing age of the population who had biopsies. CONCLUSION: This increase in kidney biopsy miss rate significantly affects patient care in the management of medical kidney disease. Its correlation with the complete reversal in operators suggests an urgent need for interaction with and training of radiologists in this critical technique.