Covalent tagging of phosphorylated peptides by phosphate-specific deoxyribozymes

[Image: see text] Phosphopeptides tagged: Phosphorylated tyrosine and serine residues in peptides are modified selectively by DNA catalysts (see the figure). The deoxyribozymes catalyze covalent attachment of an RNA tag to a range of peptide sequences, establishing proof-of-principle for a new approach to phosphopeptide analysis.