Chemical synthesis and immunological properties of oligosaccharides derived from the vegetative cell wall of Bacillus anthracis

炭疽芽孢杆菌营养细胞壁寡糖的化学合成及免疫学特性

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Abstract

Bacillus anthracis vaccine candidate: Sera of rabbits exposed to live and irradiated-killed spores of B. anthracis Sterne 34F(2) or immunized with B. anthracis polysaccharide conjugated to KLH elicited antibodies that recognize isolated polysaccharide and two synthetic trisaccharides providing a proof-of-concept step in the development of vegetative and spore-specific reagents for detection and targeting of non-protein structures of B. anthracis.

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