Abstract
OBJECTIVE: To assess the anticataleptic and antiepileptic activity of leaves of Mucuna pruriens in albino rats. MATERIALS AND METHODS: Haloperidol-induced catalepsy (HIC), maximum electro-shock (MES) method, pilocarpine-induced Status epilepticus (PISE) and single-dose effect of M. pruriens were employed. RESULTS: M. pruriens (100 mg/kg) had significant anticataleptic and antiepileptic activity in HIC, MES, and PISE. CONCLUSIONS: M. pruriens extract has the potential to be an anticataleptic and antiepileptic drug. Dopamine and 5-HT may have a role in such activity.