Abstract
OBJECTIVE: The current study sought to assess the anxiolytic effects of a methanolic extract of Biophytum sensitivum (L) DC leaves. MATERIALS AND METHODS: In vivo screening methods such as the elevated plus maze model, light and dark chamber model, and mirror chamber apparatus were used to study the anxiolytic behavior, using Wistar albino rats. Methanolic extract of B. sensitivum (MEBS) leaves and was administered orally at a dose of 200 mg and 400 mg/kg. RESULTS: The methanolic extract of the leaves of B. sensitivum exhibited a dose-dependent anxiolytic activity. CONCLUSIONS: The MEBS showed anxiolytic activity and showed results which were comparable to the standard drugs used. The total flavonoid content test confirmed the presence of flavonoids, which may have a role in the anxiolytic activity.