S-Nitrosated Polypropylene Sulfide Nanoparticles for Thiol-Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms
S-亚硝化聚丙烯硫化物纳米粒子对硫醇依赖性亚硝化和对成年雌性丝虫的毒性
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作者：Alex Schudel, Timothy Kassis, J Brandon Dixon, Susan N Thomas
Abstract
A synthetic polymer nanoparticle formulation utilizing the physiological nitrosothiol chemistry for nitric oxide delivery is shown. Toxicity of S-nitroso nanoparticles against adult female Brugia malayi worms, which are responsible for lymphatic filariasis, is dependent on nitric oxide release through transnitrosation as S-nitrosocysteine, a potent endogenous nitric oxide donor.
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