Abstract
This review article delves into the intriguing phenomenon of low-temperature thermochromism, whereby materials change color in response to temperature variations, with a particular focus on its applications in temperature-sensitive fields like medical storage. By closely examining thermochromic materials, this article highlights their potential to offer innovative solutions for monitoring and preserving thermolabile products that require strict temperature control. This leads to a special emphasis on polydiacetylenes (PDAs), a class of conjugated polymers with unique low-temperature thermochromic properties, positioning them as promising candidates for reliable temperature indicators. This article then explores the underlying mechanisms for fine-tuning the thermochromic behavior of PDAs, particularly discussing recent advancements in PDA design, such as structural alterations of monomers to achieve low-temperature thermochromism. These modifications, influenced by factors like side-chain length, hydrogen-bonding interactions, and the use of copolymers, are intended to result in irreversible color transitions at specific low temperatures, which is crucial to maintaining the integrity of thermally sensitive products. Finally, this article discusses the potential applications of PDAs as thermochromic sensors in tissue biobanking, where their ability to provide visual indications of temperature fluctuations could significantly enhance the monitoring and management of biological samples.