Abstract
OBJECTIVES: To analyze the trends, histopathological characteristics, and demographic distribution of genitourinary (GU) tumors at a major academic center in Jeddah, Saudi Arabia, over a 16-year period (2007-2023). METHODS: A retrospective review of electronic medical records was conducted, including all histologically confirmed cases of GU tumors. Data on patient demographics, tumor type, and histopathological findings were extracted and analyzed using descriptive and inferential statistical methods. RESULTS: A total of 1,791 GU tumor cases were identified. Bladder cancer was the most prevalent (42%), followed by prostate cancer (21%) and renal cell carcinoma (21%). Testicular and ureteral tumors were less common, with scrotal and penile malignancies being rare (<1%). The mean age at diagnosis varied significantly, with prostate and bladder cancers occurring predominantly in older patients, while testicular tumors were diagnosed at a younger age. A significant rise in kidney and bladder cancer diagnoses was observed, potentially linked to improved screening and environmental factors. CONCLUSION: This study provides valuable insights into the epidemiological trends of GU tumors in Saudi Arabia, emphasizing the need for early detection and targeted screening. Further research is needed to explore contributing factors and optimize treatment approaches.