Abstract
A novel carbon-11 radiolabelling methodology for the synthesis of the dialkylcarbonate functional group has been developed. The method uses cyclotron-produced short-lived [(11)C]CO(2) (half-life 20.4 min) directly from the cyclotron target in a one-pot synthesis. Alcohol in the presence of base trapped [(11)C]CO(2) efficiently forming an [(11)C]alkylcarbonate intermediate that subsequently reacted with an alkylchloride producing the di-substituted [(11)C]carbonate (34% radiochemical yield, determined by radio-HPLC) in 5 minutes from the end of [(11)C]CO(2) cyclotron delivery.