Directed Ni-Catalyzed Reductive Arylation of Aliphatic C-H Bonds

镍催化脂肪族CH键的定向还原芳基化反应

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Abstract

Herein, we describe the nickel-catalyzed reductive arylation of remote C(sp(3))-H bonds with aryl electrophiles. The reaction targets secondary and tertiary C(sp(3))-H bonds to deliver all-carbon quaternary centers. The success of this method relies on a novel amidyl radical precursor that tolerates reducing conditions, namely O-oxalate hydroxamic acid esters.

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