Abstract
Pollution generated by synthetic polymers, particularly plastics, has become a significant global environmental problem. However, when compared to polymer-derived products like microplastics, oligomers have not received the attention they deserve. Oligomers are by-products of polymer production and intermediates of degradation. Despite the industrial advancements leading to an exponential increase in the production of new polymers, a majority of oligomers have remained inadequately researched. While the exposure and toxic effects of polylactic acid oligomers have been documented, the structures and fundamental properties of oligomers derived from most polymers are still poorly understood. This knowledge gap presents challenges in establishing effective analytical methods. Considering the potential of oligomers to act as new pollutants, it is imperative to investigate their environmental behavior, as well as their absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties. This perspective highlights the research gap concerning oligomers.