Abstract
Geostatistical data aggregated at state, county, municipality, or ZIP code levels often are utilized for assessing drug overdose epidemic impact and planning resource distribution. Data aggregated at these levels may obscure critical disparities among populations experiencing high rates of drug-related mortality (DRM), especially in densely populated urban areas. Our research was centered on Cuyahoga County (Cleveland), OH, which ranks 15th in the USA for drug-related mortality. This study built on recent efforts that adopted a finer geographical lens by examining DRM rates at the census tract level. Our investigation used Cuyahoga County census tracts with high and low DRM rates and compared them with Cuyahoga County census tracts with high and low levels of opportunity as developed by a publicly available, statewide opportunity index. Analyzing DRM data from 2014 to 2022, we found that the odds of an individual experiencing DRM in low-opportunity areas were quadruple the odds for someone in high-opportunity zones. Our findings highlight the critical need for more granular geographic analysis in urban areas, where heterogenous socioenvironmental conditions appear to correlate with significant heterogeneity in the ways in which residents experience the risk of dying from a drug overdose. By focusing on smaller areas, this approach provides a clearer understanding of the DRM landscape that could facilitate the prioritization of more targeted, culturally centered, public health interventions.