Effects of condensation and compressive strain on implant primary stability: A longitudinal, in vivo, multiscale study in mice

收缩和压缩应变对种植体初始稳定性的影响:小鼠纵向、体内、多尺度研究

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作者:Zhijun Li, Masaki Arioka, Yindong Liu, Maziar Aghvami, Serdar Tulu, John B Brunski, Jill A Helms

Aims

Surgeons and most engineers believe that bone compaction improves implant primary stability without causing undue damage to the bone itself. In this study, we developed a murine distal femoral implant model and tested this dogma.

Conclusion

Collectively, these multiscale analyses demonstrate that condensation does not positively contribute to implant stability or to new peri-implant bone formation.Cite this article: Bone Joint Res. 2020;9(2):60-70.

Methods

Each mouse received two femoral implants, one placed into a site prepared by drilling and the other into the contralateral site prepared by drilling followed by stepwise condensation.

Results

Condensation significantly increased peri-implant bone density but it also produced higher strains at the interface between the bone and implant, which led to significantly more bone microdamage. Despite increased peri-implant bone density, condensation did not improve implant primary stability as measured by an in vivo lateral stability test. Ultimately, the condensed bone underwent resorption, which delayed the onset of new bone formation around the implant.

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