Abstract
[Purpose] This research work was performed to examine whether different levels of physical activity and environmental and social factors are associated with changes in adrenal hormones as markers of adrenal fatigue in Saudi adult volunteers. [Subjects and Methods] A total of 160 Saudi adults aged 15-22 years were included in this study. The adrenal fatigue score, sociodemographic attributes, and the level of physical activity were evaluated via pre-validated internet-based questionnaire surveys. Adrenal hormones such as ACTH and cortisol were measured using immunoassay techniques. [Results] Significant increases in the levels of ACTH and cortisol biomarkers were found in the participants with moderate to severe fatigue scores, poor environmental factors, and low physical activity. However, in physically active participants, significant decreases in ACTH and cortisol levels were found with remarkable improvement in adrenal fatigue status. The decrement in adrenal hormonal levels positively correlated (r= 0.976) with the improvement in adrenal fatigue status in the physically active participants. [Conclusion] Our results suggest that the level of physical activity and environmental and social factors differentially influence the adrenal fatigue status via changes in the levels of adrenal hormones. Also, ACTH and cortisol biomarkers may be useful as markers measuring the severity of adrenal fatigue.