Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

蛋白激酶 B 对核受体辅阻遏物 1 的磷酸化会改变小鼠肝脏中辅阻遏物的靶标

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作者:Young Suk Jo, Dongryeol Ryu, Adriano Maida, Xu Wang, Ronald M Evans, Kristina Schoonjans, Johan Auwerx

Conclusion

Phosphorylation-mediated recruitment switch of NCoR1 between nuclear receptor subsets provides a mechanism by which corepressors can selectively modulate liver energy metabolism during the fasting-feeding transition.

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