Ultrathin nickel-metal-organic framework nanobelt based electrochemical sensor for the determination of urea in human body fluids

基于超薄镍金属有机框架纳米带的电化学传感器用于测定人体体液中的尿素

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Abstract

Ultrathin nickel-metal-organic framework (Ni-MOF) nanobelts, [Ni(20)(C(5)H(6)O(4))(20)(H(2)O)(8)]·40H(2)O (Ni-MIL-77), have been exploited successfully for the fabrication of a non-enzymatic urea sensor. Ni-MOF ultrathin nanobelts in alkaline media can be used as an efficient catalyst for urea electrooxidation. As a non-enzymatic urea sensor, Ni-MOF ultrathin nanobelts exhibit a high sensitivity of 118.77 μA mM(-1) cm(-2), wide linear range of 0.01-7.0 mM, and low detection limit of 2.23 μM (S/N = 3). The selectivity, stability and reliability of ultrathin Ni-MOF nanobelts towards urea oxidation are also investigated. Moreover, Ni-MOF ultrathin nanobelts were further used to detect urea in human body fluids. All these findings confirm that the urea sensor based on Ni-MOF ultrathin nanobelts is successfully prepared and promising for applications in medical diagnostics and environmental monitoring.

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