A cautionary note on the naive use of general-population biobanks to study pulmonary arterial hypertension, with a focus on Mendelian randomisation

There are two issues with using existing data from general-population biobanks to study PAH: low power and non-random misclassification. Relative to gold standard data, this results in false-positive and false-negative findings. https://bit.ly/4nksm6c