Abstract
Cardiac sarcoidosis (CS) can be challenging to accurately diagnose and relies on a complex diagnostic framework because of the limited sensitivity of endomyocardial biopsy. Frequently, the diagnosis of CS depends on cardiac (18)F-fluorodeoxyglucose positron emission tomography, which has limited specificity for sarcoidosis. We report 3 cases of individuals who were initially diagnosed and treated for isolated CS based on multimodality cardiac imaging and later definitively reclassified to wild-type transthyretin cardiac amyloidosis from histopathology obtained by endomyocardial biopsy.