Abstract
BACKGROUND: Isolated native pulmonic valve endocarditis is a rare presentation of infective endocarditis. CASE SUMMARY: A female patient with a history of stage IV breast cancer requiring anterior chest wall radiation and chemotherapy presented with a 3-month course of constitutional symptoms and was found to have isolated pulmonary valve endocarditis that was medically managed with antibiotics and outpatient follow-up. DISCUSSION: Isolated native pulmonic valve endocarditis is a rare diagnosis, and pulmonic valve endocarditis can be difficult to appreciate or missed on an echocardiogram. Valvular degeneration can begin with as little as 25 Gy of radiation. TAKE-HOME MESSAGE: Valvular degeneration from chest wall radiation is a rare risk factor in developing infective endocarditis, and careful attention must be paid to the pulmonic valve if endocarditis is being considered.