Abstract
OBJECTIVE: To investigate the efficacy of Medication-Psychological-Nursing-Family-Support (MPNFS) theory-based nursing interventions in lung cancer patients undergoing chemotherapy and their impact on cancer-related fatigue (CRF) and pulmonary function. METHODS: A retrospective analysis was performed on clinical data from 92 lung cancer patients receiving chemotherapy at our institution between October 2022 and December 2024. Patients were categorized into a control group (n=46, receiving conventional nursing) and an MPNFS group (n=46, receiving MPNFS-guided nursing plus conventional care). Outcomes were compared using validated scales for CRF (Cancer Fatigue Scale, CFS), negative emotions (Self-Rating Anxiety Scale, SAS; Self-Rating Depression Scale, SDS), quality of life (EORTC QLQ-C30), nutritional status (serum albumin, ALB; total protein, TP), pulmonary function (forced vital capacity, FVC; vital capacity, VC), and complication incidence. RESULTS: CRF: After 6 weeks, cognitive, emotional, and physical fatigue scores decreased in both groups, with greater reductions in the MPNFS group (P<0.05). Negative emotions: SAS and SDS scores decreased in both groups, with more pronounced improvements in the MPNFS group (P<0.05). Quality of life: Physical, social, emotional, and role functioning scores increased in both groups, with greater gains in the MPNFS group (P<0.05). Nutritional indicators: ALB and TP levels rose in both groups, with more significant increases in the MPNFS group (P<0.05). Pulmonary function: FVC and VC improved in both groups, with superior gains in the MPNFS group (P<0.05). Complications: The MPNFS group exhibited lower incidence rates of nausea/vomiting, myelosuppression, fatigue, and malnutrition (P<0.05). CONCLUSION: Incorporating MPNFS theory-based nursing interventions alongside conventional care enhances CRF management, mitigates negative emotions, improves nutritional and pulmonary function, elevates quality of life, and reduces complication risks in lung cancer patients undergoing chemotherapy.