Abstract
OBJECTIVE: The study aimed to provide evidence for a relationship between a high dietary intake of advanced glycation end products, and periodontitis. MATERIALS AND METHODS: A total of 2334 adults from the National Health and Nutrition Examination Survey (NHANES) during 2003-2004 were included in this study. Binary regression analysis was conducted to measure the association between periodontitis and dietary advanced glycation end products (AGEs), and two adjusted models were constructed to further explore the relationship. RESULTS: Participants with AGEs intake above 21.41 U/kcal had a higher prevalence of periodontitis compared to those with lower AGEs intake. After fully adjusting for associated factors, the odds ratios for periodontitis in relation to higher AGEs intake were 1.229 (95% confidence interval 1.015-1.488, p = .034), 1.349 (95% confidence interval 1.157-1.642, p = .003), and 1.331 (95% confidence interval 1.088-1.630 p = .006), respectively. CONCLUSIONS: Our cross-sectional study reveals a strong association between periodontitis and AGEs. CLINICAL RELEVANCE: An association between advanced glycation end products in the diet and periodontitis implies the importance of the quality of food intake for good oral health. PRINCIPAL FINDINGS: The consumption of dietary advanced glycation end products is associated with an increased susceptibility to periodontitis development. PRACTICAL IMPLICATIONS: These findings contribute to recognizing the harm of advanced glycation end products in various foods to periodontitis, and guiding clinical oral education.