Abstract
BACKGROUND: We investigated changes in bone metabolism markers over time for evaluating the effect of denosumab following administration to patients with spinal metastasis. METHODS: Subjects of this study were 28 patients treated at the Department of Orthopedic Surgery at Aichi Medical University. RESULTS: At 6 months after denosumab intervention, measured TRAP-5b values were significantly lower compared to pre-intervention values in both the osteosclerotic lesion and osteolytic lesion groups. CONCLUSIONS: This change in bone metabolism marker values over time is one of the methods for evaluating the effect of treatment on bone tissue in cases of spinal metastasis.