Abstract
Cell migration is an important cellular process to study, as it plays a fundamental role in tissue structuring and development, while abnormal cell migration may be the cause of certain diseases. Among the known factors influencing cell migration, substrate curvature is one, with cells naturally moving towards concave areas while avoiding convex ones. The underlying causes of migration guidance by curvature remain unclear, and in particular, the way in which cell persistence is affected is still not well understood. We introduce an anisotropic persistent random walk model which includes cell heterogeneity to simulate T-cell migration across various corrugate landscapes. We compared the trajectories generated by the model with in vitro T-cells trajectories over the same topographies. The model accurately captures key features of cell trajectories on flat surfaces as well as on curved surfaces, such as a directional bias toward concave regions. The model also reveals a superdiffusive behavior on curvature, demonstrating more efficient movement compared to flat surfaces. The anisotropic randomness incorporated in the model appears as a critical feature which shapes T-cells persistence mechanisms by increasing cellular activity in the axis of concave valleys and promoting migration towards concave areas.