Preclinical studies of a death receptor 5 fusion protein that ameliorates acute liver failure
改善急性肝衰竭的死亡受体 5 融合蛋白的临床前研究
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作者：Qian Chen, Pu Wang, Qingmei Zhang, Meng Xia, Guizhong Zhang, Junxin Li, Enyun Shen, Youhai H Chen, Xiaochun Wan
Key messages
sDR5-Fc binds with high affinity to TRAIL to effectively block TRAIL-induced apoptosis. sDR5-Fc ameliorates Con A-induced acute liver failure in mice by inhibiting hepatocyte death and inflammation. sDR5-Fc or TRAIL knockout attenuates the production of inflammatory cytokines by activated splenocytes in vitro. sDR5-Fc is safe and well tolerated in acute or long-term toxicity study.
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