Abstract
AIMS: We aimed to explore the relationship of noise exposure in the workplace, genetic risk, and lifestyle with Type 2 diabetes (T2D). METHODS: A total of 154,708 participants without T2D in UK Biobank were included. A lifestyle score was determined using smoking, alcohol intake, physical activity, television viewing time, sleep duration, and diet. RESULTS: During a median follow-up of 11.83 years (1,776,919.62 person-years), 5921 T2D cases were observed. Compared to no noise exposure, the hazard ratios (HRs) and 95% confidence intervals (CIs) were 1.06 (0.95-1.18) in less than a year, 1.01 (0.91-1.12) in around 1-5 years, and 1.11 (1.04-1.20) in more than 5 years, respectively. Compared to participants with low genetic risk and no noise exposure, individuals with high genetic risk and noise exposure for more than 5 years did not show the highest risk of T2D (HR = 1.16, 95%CI = 0.98-1.36). However, participants with the least healthy lifestyle and noise exposure for more than 5 years revealed a higher risk of T2D (HR = 1.72, 95%CI = 1.27-2.33). CONCLUSIONS: Prolonged noise exposure in the workplace is related to a higher risk of T2D.