Abstract
The implant-to-tissue interface is an extremely dynamic region of interaction. Generally, a surgical procedure is performed on a patient to insert a foreign material into the bone, and the body is called on to "heal" the wound. The time schedule crucial for a healing process that is expected to result in restitution ad integrum must be determined with respect to the condition of the individual patient and tissue to be treated. There are various factors responsible for the formation of an adequate bone-implant interface. A comprehensive review of the response of bone to implant is described.